Big enchilada is a slang phrase that means "the man or woman in charge." At a high school, the principal is usually the big enchilada.
Use the term big enchilada when you need an extremely casual way to refer to your boss, or to someone who is otherwise the top dog or head honcho. Most word experts think that big enchilada, which was first used in the 1970's, was a spin-off of the earlier idiom big cheese, also a slang term for a boss or leader.